Neurobiology of Disease Persistent Increase in Olfactory Type G-Protein Subunit Levels May Underlie D1 Receptor Functional Hypersensitivity in Parkinson Disease
نویسندگان
چکیده
Jean-Christophe Corvol,1 Marie-Paule Muriel,2 Emmanuel Valjent,1 Jean Féger,2 Naı̈ma Hanoun,3 Jean-Antoine Girault,1 Etienne C. Hirsch,2 and Denis Hervé1 1Institut National de la Santé et de la Recherche Médicale (INSERM)–Université Pierre et Marie Curie Unité 536, Institut du Fer à Moulin, 75005 Paris, France, 2INSERM Unité 289, Centre Hospitalier Universitaire Pitié-Salpétrière, 75013 Paris, France, and 3INSERM Unité 288, Fac Médecine PitiéSalpétrière, 75013 Paris, France
منابع مشابه
Dopamine-Induced Changes in Gαolf Protein Levels in Striatonigral and Striatopallidal Medium Spiny Neurons Underlie the Genesis of l-DOPA-Induced Dyskinesia in Parkinsonian Mice
The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson's disease (PD). LID has a close link with deregulation of striatal dopamine/cAMP signaling, which is integrated by medium spiny neurons (MSNs). Olfactory type G-protein α subunit (Gαolf), a stimulatory GTP-binding ...
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